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[Molecular aspects of allergy to plant products. Part III. Panallergens and breeding of hypoallergenic cultivars].

Identifieur interne : 000208 ( Main/Exploration ); précédent : 000207; suivant : 000209

[Molecular aspects of allergy to plant products. Part III. Panallergens and breeding of hypoallergenic cultivars].

Auteurs : Kamila Bokszczanin [Pologne] ; Andrzej A. Przybyła

Source :

RBID : pubmed:22708284

Descripteurs français

English descriptors

Abstract

In addition to major allergens, also minor allergens, i.e. panallergens have been shown to be responsible for many IgE cross-reactions even between unrelated pollen and plant food allergen sources. It can be explained also by cross-allergenicity underlying the T cell response to conserved regions of panallergens. In this article, we focus on known panallergens which presently comprise a few protein families, including non-specific lipid transfer proteins (nsLTP) (PR-14), thaumatin like proteins (TLP) (PR-5), profilins, and polcalcins. Food allergy has an impact on the quality of life of an allergic patient. The way of developing novel plant cultivars with decreased allergenicity and possibility of down-regulating the expression of an allergen by genetic modification are discussed.

PubMed: 22708284


Affiliations:


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Le document en format XML

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<title xml:lang="en">[Molecular aspects of allergy to plant products. Part III. Panallergens and breeding of hypoallergenic cultivars].</title>
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<term>Breeding (MeSH)</term>
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<term>Réactions croisées (immunologie)</term>
<term>Régulation négative (MeSH)</term>
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<div type="abstract" xml:lang="en">In addition to major allergens, also minor allergens, i.e. panallergens have been shown to be responsible for many IgE cross-reactions even between unrelated pollen and plant food allergen sources. It can be explained also by cross-allergenicity underlying the T cell response to conserved regions of panallergens. In this article, we focus on known panallergens which presently comprise a few protein families, including non-specific lipid transfer proteins (nsLTP) (PR-14), thaumatin like proteins (TLP) (PR-5), profilins, and polcalcins. Food allergy has an impact on the quality of life of an allergic patient. The way of developing novel plant cultivars with decreased allergenicity and possibility of down-regulating the expression of an allergen by genetic modification are discussed.</div>
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